Dynamic oxygen-enhanced MRI in patients with pulmonary arterial hypertension
نویسندگان
چکیده
Introduction: Oxygen-enhanced MRI (O2-MRI) of the lung is based on the T1-shortening effect of oxygen (O2) inhalation and provides combined information about pulmonary ventilation, perfusion, and diffusion [1–9]. Dynamic O2-MRI acquires (in each pixel) the signal time course influenced by the alternating administration of room air and O2. By fitting a model function (pixelwise) to the acquired data, several parameters such as the relative signal increase, the signal delay as well as the O2 wash-in and wash-out time constants can be obtained [2,4,6,8,9]. The purpose of this study was to determine the value of dynamic O2-MRI in patients with pulmonary arterial hypertension (PAH) by comparing the distributions of the fitted parameters with those found in healthy volunteers.
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